Endep (Amitriptyline) 10,25,50,75 mg Pills

1707-13When buy Endep, you’ll notice a lot of interesting facts about this medication and the range of its action, which is rather wide. The mechanism of antidepressant action is associated with increased concentrations of norepinephrine in the synapses and serotonin in the CNS through oppression reverse neuronal capture of these mediators. Prolonged Endep use reduces the functional activity of β-adrenergic and serotonergic brain receptors, normalizes adrenergic and serotonergic transmission, and restores the balance of these systems which are disrupted in depressive condition. When anxiety and depressive conditions, Endep reduces anxiety, agitation and depressive manifestations.

Besides, after you decided to buy Endep you see that it’s also has some analgesic effect, which is believed to be associated with changes in concentrations of monoamines in the CNS, especially serotonin, and the impact on the endogenous opioid system.

Endep 150 mg possesses strong peripheral and central anticholinergic effects associated with high affinity for m-cholinergic receptors, a strong sedative effect connected with affinity for histamine H1-receptors and alpha-adrenoceptor blocking action.

Also, 400mg Endep has antiulcer effect mechanism, due to which it’s blocked histamine H2-receptors in parietal cells of the stomach, and this leads to anticholinergic effects of m-(with gastric ulcer and duodenal ulcer reduces pain, accelerates healing of ulcers).

The mechanism of Endep therapeutic action with bulimia nervosa is not noticed (possibly similar to that for depression). While Endep use, it was demonstrated a clear efficacy of amitriptyline in bulimia patients with or without depression.

In the conduct of general anesthesia, Endep reduces blood pressure and body temperature. Endep doesn’t inhibit MAO. Antidepressive action develops within 2-3 weeks after the start of application.

With simultaneous application of chemotherapy, Endep have a depressing effect on the central nervous system, possibly a considerable increase in inhibitory action on the central nervous system, hypotensive effect, respiratory depression. With simultaneous use with drugs having anticholinergic activity, probably increased anticholinergic effects.

If you buy Endep, notice that with the simultaneous use of MAO inhibitors it may develop a hypertensive crisis.

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